Endocrine Abstracts

Objective: To evaluate the evolution of glycemic control in a cohort of patients with type 2 diabetes mellitus (T2DM) after its assessment in endocrinology.Methods: Prospective cohort study. 465 patients with T2DM who were not followed up at an endocrinology clinic were included. This study was approved by the Ethics and Clinical Research Committee of the University Hospital of Guadalajara.Results: Mean age was 63.4±12.5 years...

BackgroundSuspicion of Cushing´s syndrome (CS) is usually suggested by non-specific clinical data. Chronic hypercortisolism associates changes in white blood cell count (WBC), essentially a higher count with relative lymphopenia. Our purpose is to investigate the prevalence of these findings among a local series of patients with Cushing’s syndrome before and after the hypercortisolism revertion to assess the diagnostic value of these parameters...

Undifferentiated thyroid carcinomas are extremely aggressive and currently lack effective treatment. Aberrant RAS-ERK signaling, triggered mainly by BRAF and RAS mutations, is responsible for the occurrence and progression of most thyroid carcinomas, which led to the clinical use of small kinase inhibitors targeting kinases of the pathway. The results were disappointing, because of the emergence of resistance and high-associated toxicity. A more specific approach, targeting si...

Background: Mild autonomous cortisol secretion (MACS) in patients with adrenal incidentalomas has been associated with elevated cortisol levels during the nocturnal period resulting in a disturbed cortisol rhythm. We hypothesised that administration of nocturnal metyrapone, an 11-beta-hydroxylase inhibitor, previously shown to restore cortisol rhythm in MACS patients, could reduce metabolic complications in this patient group.Met...

Background: Diamond Blackfan anaemia (DBA) is a condition caused by mutations in ribosomal protein genes. After the first year of life, the mainstay of treatment is corticosteroids whilst red blood cell transfusions are used for patients who do not respond.Case: We present a case of a 20-year-old woman with a history of DBA (RPS19 mutation), initially treated with courses of prednisolone, who aged 3 developed steroid-ind...

Introduction: Adrenal masses (AM) are being increasingly diagnosed but only a small portion will need surgical treatment.Methods: We retrospectively reviewed patients referred to the Endocrinology Clinic that underwent adrenalectomy between 1996 and 2023.Results: We included 57 patients. Most AM were diagnosed incidentally (53%) and had a median size of 32 (25) mm. Forty (70%) patients had hormonal hypersecretion (HH): pheocromocyt...

Introduction: Hypoaldosteronism can be induced by a deficit of aldosterone production (AldDef) or a mineralocorticoid resistance (MinRes). Experts have proposed to use hyperkalemia-based aldosterone values for this purpose. However, there is no a range of aldosterone values indicating one of this type of hypoaldosteronism. In 2008, Adam W. R.1 hypothesized that the factored aldosterone (FAldo) could be useful differentiating hypoaldosteronism secondary to MinRes fro...

Background: Thyroid nodules are one of the most common clinical entities in Endocrinology practice. Fine needle aspiration (FNA) and the 2017 Bethesda System for Reporting Thyroid Cytopathology have been proved to be an effective tool to identify malignancy risk and guide surgical decision-making. However, thyroid nodules classified as Bethesda (BTH) III and IV remain a challenge, considering the varying risk of malignancy (ROM) found in different papers. The aim of this study...

Background: Thionamides are a class of drugs used to control thyrotoxicosis. A wide range of systemic adverse effects have been described, including agranulocytosis, rash, fever, arthralgia, hepatitis and even drug-induced lupus. Besides, there are some uncommon events related to their use, such as pleural effusion (only eight cases have been previously reported). We report a case of methimazole-induced eosinophilic pleural effusion.Case: Our patient is ...

Background: Premature ovarian failure (POF) due to cyclophosphamide (Cyc) therapy is well documented in systemic lupus erythematosus (SLE) patients. Studies show that the use of gonadotropin releasing hormone (GnRH) analogues appears to protect women from POF. We present our experience in SLE patients treated with triptorelin.Methods: Observational study of 15 women diagnosed of SLE who have received concomitant treatment with Cyc and GnRH analogues (tri...